Enpp-1-IN-14

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

ENPP1-IN-2 是外核苷酸焦磷酸酶/磷酸二酯酶-1 (ENPP1) 的有效抑制剂，对重组人 ENPP-1 的 IC50 值为 32.38 nM。 ENPP1-IN-2 具有抗肿瘤活性。

ENPP1-IN-2 is a potent inhibitor of Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 (ENPP1) with an IC50 value of 32.38 nM for recombinant human ENPP-1. ENPP1-IN-2 has anti-tumor activity.(In Vivo):ENPP1-IN-2 (compound 015) (50 mg/kg; IP; BID, for 31 days) significantly inhibits tumor growth in Female C57BL/6 mice (4-6 weeks; implanted subcutaneously with 2×105 MC38 cells).

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Enpp-1-IN-14 (compound 015) (50 mg/kg; IP; BID, for 31 days) significantly inhibits tumor growth. Animal Model:Female C57BL/6 mice (4-6 weeks; implanted subcutaneously with 2×105 MC38 cells)Dosage:50 mg/kg Administration:IP; BID, for 31 days (given a single 10 Gy exposure of focal radiation to the tumor site)Result:Significantly inhibited tumor growth.

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Angiogenesis

PDE

KSP

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2687222-59-7

403.88

C15H22ClN5O4S

>98% (HPLC)

In Vitro:?DMSO : 9.62 mg/mL (23.82 mM)

Cl.O=S(=O)(N)N1CCN(C=2N=CN=C3C=C(OC)C(OC)=CC32)CCC1

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(-20℃)

With Ice Pack

≥ 2 years