Sardomozide

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Sardomozide 是 S-腺苷甲硫氨酸脱羧酶 (SAMDC, IC50 = 5 nM) 的抑制剂。

Sardomozide is an inhibitor of S-adenosylmethionine decarboxylase (SAMDC, IC50 = 5 nM).(In Vitro):In CHO/664 cells treated with DENSPM, Sardomozide inhibits cell growth without vacuole formation. Sardomozide (3 μM) reduces intracellular SAMDC activity to 10%.

Sardomozide is a S-adenosylmethionine decarboxylase (SAMDC) inhibitor with an IC50 of 5 nM in cell assay. Following treatment for 48 h with 3 μM Sardomozide, intracellular SAMDC activity is reduced to 10% of control. When the CHO/664 cells are grown in the presence of Sardomozide and during treatment with DENSPM, vacuole formation is not observed, and these cells are growth-inhibited and contain levels of DENSPM similar to the parental CHO cells.

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CGP 48664 dihydrochloride

Others

Other Targets

Platelet aggregation

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138794-73-7

303.19

C11H16Cl2N6

>98% (HPLC)

In Vitro:?DMSO : 10 mg/mL (32.98 mM)

N=C(C1=CC=CC2=C1CCC2=NNC(N)=N)N.[H]Cl.[H]Cl

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(-20℃)

With Ice Pack

≥ 2 years