(E)-Ferulic acid methyl ester

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Mmethyl (E)-ferulate 是一种可能的丝裂原激活磷酸激酶途径抑制剂，它可能是首次从药用植物马铃薯中分离出来的潜在抗炎剂。甲基 (E)-阿魏酸对捻转血矛线虫具有良好的驱虫活性。

Methyl (E)-ferulate is a possible inhibitor of the mitogen activated phosphor kinase pathway, it could be a potential anti-inflammatory agent isolated for the first time in medicinal plant S. tuberosa. Methyl (E)-ferulate has promising anthelmintic activity against Haemonchus contortus.(In Vitro):The objective of this study is to evaluate the toxicity of Methyl ferulate (MF), methyl p-coumarate (MpC), and pulegone 1,2-epoxide (PE) with in vitro and in vivo assays. METHODS AND RESULTS:The in vitro toxicity of Methyl ferulate, MpC, and PE was assessed at a concentration of 10 mg/ml with the Ames assay using two strains of Salmonella typhimurium TA98 and TA100. Human red blood cells (RBC) were used to determine the hemolytic activity of these compounds. PE produced 6-8% hemolysis of RBCs at all the tested concentrations while Methyl ferulate and MpC produced 10-5% hemolysis up to 20 mg/ml, and 50-85% hemolysis at concentrations of 40 and 80 mg/ml, respectively. The Ames assay indicated that Methyl ferulate, MpC, and PE were non-mutagenic as the test values were not significantly higher as compared with background values of the assay. BSLB suggested the lethal concentration (LC50) values of Methyl ferulate, MpC, and PE as 4.38, 6.74, and 25.91 mg/ml, respectively. In vivo ocular and dermal irritation scores of Methyl ferulate, MpC, and PE were comparable with ethanol (control) in rabbits indicating the non-irritant nature of these natural compounds. CONCLUSIONS:The present studies suggest that these compounds are non-toxic/non-irritant and might be used for medicinal purposes.

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Methyl (E)-ferulate | Methyl (E)-ferulate

Apoptosis

IL Receptor

GluR1|GluR3|GluR5|AMPAR

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22329-76-6

208.21

C11H12O4

>98% (HPLC)

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COC(/C=C/c(cc1)cc(OC)c1O)=O

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(-20℃)

With Ice Pack

≥ 2 years