ML-148

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

ML-148 是 15-羟基前列腺素脱氢酶 (15-PGDH，IC50 = 56 nM) 的选择性抑制剂。

ML-148 is a selective inhibitor of 15-hydroxy prostaglandin dehydrogenase (15-PGDH, IC50 = 56 nM). ML-148 can be used to profile across a panel of related dehydrogenase or reductase enzymes and in studies about prostaglandin-signaling pathways.(In Vitro):ML148 (10 nM) reduces the apparent Km by half and decreases Vmax by 25%. ML148 shows selectivity with IC50s of 36000, >57500, >57500 nM for ALDH1A1, HADH2, HSD17β4, respectively.

ML148 (compound 13) shows selectivity with IC50s of 56, 36000, >57500, >57500 nM for 15-PGDH, ALDH1A1, HADH2, HSD17β4, respectively.ML148 (10, 20 nM) decrease Vmax by 25% and reduces the apparent Km by half at a concentration of 10 nM.

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Metabolic Enzyme/Protease

Dehydrogenase

GPR52

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451496-96-1

319.4

C20H21N3O

>98% (HPLC)

In Vitro:?DMSO : 50 mg/mL (156.54 mM)

O=C(C=1C=CC2=C(N=CN2C3=CC=CC(=C3)C)C1)N4CCCCC4

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(-20℃)

With Ice Pack

≥ 2 years