TUG-469

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

TUG-469 是一种有效的游离脂肪酸 1 受体激动剂。

TUG-469 is an effective free fatty acid 1 receptor agonist.

TUG-469 (0-10 μM) shows efficacy to hFFA1 with a pEC50 value of 7.73.TUG-469 (10 μM) increases the insulin secretion under 10 mM glucose stimulation.TUG-469 (0-100 μM) is >200-fold selective for FFA1 over FFA4 with EC50 values of 19 nM and 4.4 μM for FFA1 and FFA4, respectively.TUG-469 (5 μM; 30 min) significantly increases insulin secretion of INS-1 cells with the presence of high glucose concentration (16.7 mM).

TUG-469 (5 mg/kg; i.p.; 60 and 90 min after glucose administration) affects blood glucose level. Animal Model:Male NZO mice with glucose administration Dosage:5 mg/kg Administration:Intraperitoneal injection; 5 mg/kg; 60 and 90 min after glucose administration Result:Reduced the blood glucose level.

TUG469 | TUG 469

Others

Other Targets

Influenza virus|neuroprotection|Antifection

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1236109-67-3

345.442

C23H23NO2

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (289.49 mM)

Cc1ccccc1-c1cccc(CNc2ccc(CCC(O)=O)cc2)c1

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(-20℃)

With Ice Pack

≥ 2 years