RK-9123016

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

RK-9123016 是一种 SIRT2 抑制剂。 RK-9123016 增加真核翻译起始因子 5A (eIF5A)（SIRT2 的生理底物）的乙酰化水平，并降低人乳腺癌细胞的细胞活力，同时降低 c-Myc 表达。

RK-9123016 is a SIRT2 inhibitor. RK-9123016 increases the acetylation level of eukaryotic translation initiation factor 5A (eIF5A), a physiological substrate of SIRT2, and reduces cell viability of human breast cancer cells accompanied with a decrease in c-Myc expression.(In Vitro):RK-9123016 inhibited the enzymatic activity of SIRT2 with an IC50 value of 0.18 μM but not other human sirtuin members including SIRT1 and SIRT3 at 100 μM in vitro electrophoretic mobility shift assay. RK-9123016 inhibited the SIRT2 activity in MCF-7 cells by concentration dependent manner (0-30 μM).

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RK 9123016 | RK9123016

Chromatin/Epigenetic

Sirtuin

Fatty Acid Synthase (FASN)

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955900-27-3

374.42

C16H18N6O3S

>98% (HPLC)

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COc1ccc(\C=N\NC(=S)NCC=C)cc1Cn1cc(cn1)[N+]([O-])=O

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(-20℃)

With Ice Pack

≥ 2 years