Inz-1

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Inz-1 是一种有效的真菌选择性线粒体细胞色素 bc1 抑制剂，对酵母和人类的 IC50 分别为 8.092 和 45.320 μM。

Inz-1 is an effective and fungal-selective inhibitor of mitochondrial cytochrome bc1 with IC50s of 8.092 and 45.320 μM for yeast and human. Inz-1 reverses Fluconazole or other triazole antifungals’ resistance in the pathogenic fungus Candida albicans.(In Vitro):Inz-1 against Candida and HepG2 respiring growth with IC50 values of 1.655 uM and >32 μM, respectively. Inz-1 (0-16 μM; 24 hours) inhibits the growth of the model yeast S. cerevisiae (strain BY4741) and C. albicans (SC5314) in media containing glucose or glycerol as the sole carbon source, while only mildly slowing growth in glucose. Inz-1 (0-100 μM; 24 hours) shows inhibition of yeast cytochrome B enzymatic activity in a concentration -dependent manner in both wild-type and F90Y mutant mitochondria. It exhibits inhibition of cytochrome bc1 from both S. cerevisiae and C. albicans with IC50 value of 2.5 μM and 8.0 μM, respectively. Inz-1 (0-100 μM; 24 hours) inhibits proliferation under forced respiration conditions only at 32 μM and only mildly at that concentration.

Inz-1 (0-16 μM; 24 hours) inhibits the growth of the model yeast?S. cerevisiae?(strain BY4741) and?C. albicans?(SC5314) in media containing glucose or glycerol as the sole carbon source, while only mildly slowing growth in glucose.?Inz-1 (0-100 μM; 24 hours) shows inhibition of yeast cytochrome B enzymatic activity in a concentration -dependent manner in both wild-type and F90Y mutant mitochondria. It exhibits inhibition of cytochrome bc1 from both?S. cerevisiae and?C. albicans?with IC50 value of 2.5 μM and 8.0 μM, respectively.Inz-1 (0-100 μM; 24 hours) is selective for yeast over human cytochrome bc1, it inhibits human cytochrome bc1 activity only weakly, with an IC50?of 45.3 μM, 5.6-fold higher than the IC50?for the?C. albicans?homolog in mitochondria purified from HEK293 human embryonic kidney cells.Inz-1 (0-100 μM; 24 hours) inhibits proliferation under forced respiration conditions only at 32 μM，and only mildly at that concentration.Inz-1 is against candida, human enzyme with IC50 values of 8.092μM and 45.320 μM, respectively. It against Candida and HepG2 respiring growth with IC50 values of 1.655 uM and >32 μM, respectively.

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Inz1 | Inz 1

Metabolic Enzyme/Protease

P450

Carbonic anhydrase

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897776-15-7

266.3

C16H14N2O2

>98% (HPLC)

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COC(=O)Cn1nc(-c2ccccc2)c2ccccc12

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(-20℃)

With Ice Pack

≥ 2 years