021-51111890
购物车（）
sales@molnova.cn
BAY 73-1449
CAS No. 693790-96-4
BAY 73-1449 ( BAY73-1449 | BAY 73-1449 )
产品货号. M27855 CAS No. 693790-96-4
BAY 73-1449 是一种选择性且有效的前列环素受体拮抗剂（IC50<0.1 nM）。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥785 | 有现货 |
|
| 10MG | ￥1169 | 有现货 |
|
| 25MG | ￥1925 | 有现货 |
|
| 50MG | ￥2678 | 有现货 |
|
| 100MG | ￥3501 | 有现货 |
|
| 200MG | ￥4707 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥751 | 有现货 |
|
生物学信息
-
产品名称BAY 73-1449
-
注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
-
产品简述BAY 73-1449 是一种选择性且有效的前列环素受体拮抗剂（IC50<0.1 nM）。
-
产品描述BAY 73-1449 is a selective and potent antagonist of the prostacyclin receptor(IC50<0.1 nM).(In Vivo):In male Wistar rats, BAY 73-1449 (0.1-1 mg/kg; i.v.) significantly reduced splenic shunt vessel outflow without affecting mesenteric inflow. BAY 73-1449 (1-5 mg/kg; s.c.) has no effects on portal pressures and the degree of porto-systemic shunting in rats.
-
体外实验——
-
体内实验BAY 73-1449 (0.1-1 mg/kg; i.v.) does not significantly reduce mesenteric inflow, but significantly reduces splenic shunt vessel outflow in rats.BAY 73-1449 (1-5 mg/kg, s.c. once daily for 7 d) has no effects on the degree of porto-systemic shunting in rats.BAY 73-1449 (1 mg/kg, s.c. once daily for 7 d), has no effects on portal pressures in rats. Animal Model:Male Wistar rats (250-350 g) are ligated portal veinDosage:0.1, 1 mg/kg.Administration:A single i.v.Result:Significantly reduced shunt flow without affecting mesenteric flow.
-
同义词BAY73-1449 | BAY 73-1449
-
通路Others
-
靶点Other Targets
-
受体RhoA| Lbc
-
研究领域——
-
适应症——
化学信息
-
CAS Number693790-96-4
-
分子量425.488
-
分子式C26H23N3O3
-
纯度>98% (HPLC)
-
溶解度In Vitro:?DMSO : 250 mg/mL (587.57 mM)
-
SMILESOC(=O)[C@H](Cc1ccccc1)Nc1cc(ncn1)-c1ccc(OCc2ccccc2)cc1
-
化学全称——
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1.Francesca FANELLI, et al. Compounds and composition for use in the inhibition of the lbc-rhoa interaction, in particular for the treatment of cancer. WO2015028929A1.
产品手册
关联产品
-
HJC0197
HJC0197 选择性阻断 cAMP 诱导的 Epac 激活。 HJC0197 是一种有效的交换蛋白。其直接被 cAMP (Epac) 拮抗剂激活（对于 Epac2，IC50=5.9 μM）。
-
GRP (porcine)
Mammalian bombesin-like peptide neurotransmitter that is an agonist for the gastrin-releasing peptide receptor (GRPR). GRP has been reported to activate GABAergic interneurons in the amygdala leading to increased GABA release and fear suppression in mice in vivo. Also involved in mitogenesis, and GI tract and appetite regulation.
-
N-Biotinyl-1,6-hexan...
N-Biotinyl-1,6-hexanediaMine (Biotinyl hexylamine) is a synthetic intermediate that can be used to synthesize nanomedicines and chemotherapeutic couplers.
