AZ13705339

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

AZ13705339 是一种有效的选择性 PAK1 抑制剂，IC50 为 0.33 nM。

AZ13705339 is a potent and selective PAK1 inhibitor with IC50 of 0.33 nM.(In Vitro):AZ13705339 (300 nM) prevents Siglec-8 binding-induced eosinophil death. In Namalwa cells, AZ13705339 (1 μM) inhibits αIgM-controlled but not PMA-induced adhesion.(In Vivo):In rats, AZ13705339 (100 mg/kg, p.o.) exhibits moderate clearance and Cmax of 7.7 μM.

AZ13705339 (1 μM) inhibits αIgM-controlled adhesion and not PMA-induced adhesion in Namalwa cells.AZ13705339 (300 nM, 30 min) prevents Siglec-8 engagement-induced eosinophil death.

AZ13705339 (100 mg/kg, P.O.) has moderate clearance and oral Cmax of 7.7 μM in rats.

AZ-13705339 | AZ 13705339

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2016806-57-6

629.76

C33H36FN7O3S

>98% (HPLC)

In Vitro:?DMSO : 250 mg/mL (396.98 mM)

CCS(=O)(=O)c1cc(Nc2ncc(F)c(n2)N(Cc2ccccc2C#N)c2cc(CO)ccc2C)ccc1N1CCN(C)CC1

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(-20℃)

With Ice Pack

≥ 2 years