Amitivir

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

阿米替韦是一种肌苷单磷酸脱氢酶抑制剂。阿米替韦抑制分裂的 MDCK 细胞的复制。

Amitivir is an inosine monophosphate dehydrogenase inhibitor. Amitivir inhibits the replication of dividing MDCK cells. Amitivir was associated with asymptomatic rises in serum uric acid levels and was ineffective in modifying the virologic or clinical course of experimental influenza A (H1N1) virus infection.

The mean 50% inhibitory concentration of Amitivir inhibits six strains of type A influenza (A/Russia, A/Brazil/11/78, A/Ann Arbor/1/57, A/Port Chalmers/1/73, A/Hong Kong/8/68 and A/X-15) ranged from 0.37 to 1.19 μg/ml. The mean 50% inhibitory concentration of Amitivir inhibits four strains of influenza B virus (B/Maryland/11/59, B/GreatLakes/1739/54, B/Singapore/3/64, B/Lee/40) ranged from 0.75 to 1.54 μg/ml.

Amitivir (LY 217896) (9 mg/m2 of body surface area per day) administered in the diet, in the drinking water, by oral gavage, by intraperitoneal injection, or by aerosolization was well tolerated and protected CD-1 mice infected with a lethal dose of influenza A or B virus.

LY-217896 | LY 217896 | LY217896

Others

Other Targets

lipase

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111393-84-1

126.14

C3H2N4S

>98% (HPLC)

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N#CNC1=NN=CS1

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(-20℃)

With Ice Pack

≥ 2 years