5J-4

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

5J-4 是钙释放激活钙 (CRAC) 通道和钙库操纵钙进入 (SOCE) 的强效阻滞剂。 5J-4 减少 IL-17 的产生并降低 RORα 和 RORγt 的表达。

5J-4 is a potent a blocker of calcium release-activated calcium (CRAC) channel and store-operated calcium entry (SOCE). 5J-4 reduces the production of IL-17 and decreases the expression of RORα and RORγt.(In Vivo):5J-4 (2 mg/kg; i.p.; every alternate day for 30 days) dramatically reduced the symptoms and delayed the onset of EAE and decreased the numbers of the infiltrated mononuclear cell in the CNS, and significantly decreased the population of infiltrated CD4+ population. 5J-4 reduced the symptoms and delayed the onset of EAE (experimental autoimmune encephalomyelitis) in the mouse model of inflammation.

——

5J-4 reduces the production of IL-17 and decreases the expression of RORα and RORγt.5J-4 (2 mg/kg; i.p.; every alternate day for 30 days) reduces the symptoms and delayed the onset of EAE. Animal Model:C57BL/6 mice (MOG35-55 peptide-immunized mice)Dosage:2 m/kg Administration:I.p., every alternate day for 30 days Result:Dramatically reduced the symptoms and delayed the onset of EAE and decreased the numbers of infiltrated mononuclear cell into the CNS, and significantly decreased the population of infiltrated CD4+ population.

5J 4 | 5J4

GPCR/G Protein

Calcium Channel

CDK4|CDK6

——

——

827001-82-1

312.34

C16H12N2O3S

>98% (HPLC)

——

Oc1ccc2c(NC(=S)NC(=O)c3ccco3)cccc2c1

——

(-20℃)

With Ice Pack

≥ 2 years