Oxotremorine sesquifumarate

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Oxotremorine sesquifumarate 是一种毒蕈碱受体激动剂。

Oxotremorine sesquifumarate is a muscarinic receptor agonist.(In Vitro):Oxotremorine (10.5 micron) produced a paralytic effect on twitch responses of rat diaphragm in vitro to direct and indirect stimulation.(In Vivo):Rats with signs of neuropathy were subjected to SCS applied in awake, freely moving condition. Oxotremorine was administered intrathecally. Tactile, cold and heat sensitivities were assessed by using von Frey filaments, cold spray and focused radiant heat, respectively. Oxotremorine i.t. dose-dependently suppressed the tactile hypersensitivity. SCS markedly increased withdrawal thresholds (WTs), withdrawal latencies and cold scores.

Oxotremorine (10.5 μM) produces a paralytic effect on twitch responses of rat diaphragm in vitro to direct and indirect stimulation.

In rats with sciatic nerve injuries, Oxotremorine (10, 5, 21 μg; 10 μL) i.t. dose-dependently suppresses the tactile hypersensitivity.

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Cell Cycle/DNA Damage

AChR

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17360-35-9

760.794

C36H48N4O14

>98% (HPLC)

In Vitro:?DMSO : 125 mg/mL (328.60 mM)

OC(=O)\C=C\C(O)=O.OC(=O)\C=C\C(O)=O.OC(=O)\C=C\C(O)=O.O=C1CCCN1CC#CCN1CCCC1.O=C1CCCN1CC#CCN1CCCC1

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(-20℃)

With Ice Pack

≥ 2 years