BMS 193885

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

BMS-193885 是一种有效的选择性神经肽 Y1 受体拮抗剂 (IC50: 5.9nM)。

BMS-193885 is an effective and selective neuropeptide Y1 receptor antagonist (IC50: 5.9nM).(In Vitro):BMS 193885 increases the Kd of [(125)I]PeptideYY from 0.35 nM to 0.65 nM without changing the Bmax (0.16 pmol/mg of protein) in SK-N-MC cells that endogenously express the neuropeptide Y(1) receptor. BMS 193885 is a full antagonist with an apparent Kb of 4.5 nM measured by reversal of forskolin-stimulated inhibition of cAMP production by neuropeptide Y.(In Vivo):BMS 193885 (10 mg/kg; i.p.) reduces one-hour neuropeptide Y-induced food intake in satiated rats, as well as spontaneous overnight food consumption. Chronic administration of BMS 193885 (10 mg/kg) i.p. for 44 days significantly reduces food intake and the rate of body weight gain compared to vehicle treated control without developing tolerance or affecting water intake.

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BMS193885

Others

Other Targets

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679839-66-8

680.799

C36H48N4O9

>98% (HPLC)

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[H][C@@](C)(O)C(O)=O.COC(=O)C1=C(C)NC(C)=C(C1c1cccc(N\C(O)=N\CCCN2CCC(CC2)c2cccc(OC)c2)c1)C(=O)OC

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(-20℃)

With Ice Pack

≥ 2 years