Tropisetron

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Tropisetron 是一种 α7-烟碱受体激动剂和 5-HT3 受体拮抗剂，Kis 分别为 6.9 nM 和 5.3 nM。

Tropisetron is an α7-nicotinic receptor agonist and 5-HT3 receptor antagonist with Kis of 6.9 nM and 5.3 nM, respectively.(In Vitro):The IC50 value of Tropisetron for the 5-HT3 receptor is 70.1 ± 0.9 nM. Tropisetron inhibits IL-2 production and antigen-induced proliferation in human peripheral T cells and inhibits signaling pathways that regulate the activation of transcription factors AP-1, NFAT, and NF-κB.(In Vivo):Tolbisetron induces anti-inflammatory effects in experimental models of cisplatin-induced nephrotoxicity that are completely independent of the 5-HT3 receptor. Tropisetron can improve ischemic brain injury by reducing TNF-α levels and myeloperoxidase activity.

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ICS 205-930 | Tropisetronum | Tropisteron

Endocrinology/Hormones

5-HT Receptor

TRPM8

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89565-68-4

284.359

C17H20N2O2

>98% (HPLC)

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CN1C2CCC1CC(C2)OC(=O)c1c[nH]c2ccccc12

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(-20℃)

With Ice Pack

≥ 2 years