Aminopurvalanol A

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Aminopurvalanol A 是一种竞争性、选择性和细胞渗透性的细胞周期蛋白依赖性激酶 (CDK) 抑制剂，可有效抑制 Cyclin A/cdk2、Cyclin B/cdk1、Cyclin E/cdk2 和 P35/cdk5，IC50 为 33 nM、33 nM 、 28 nM 和 20 nM 。

Aminopurvalanol A is a competitive, selective and cell-permeable inhibitor of cyclin-dependent kinase (CDK) that potently inhibits Cyclin A/cdk2, Cyclin B/cdk1, Cyclin E/cdk2, and P35/cdk5 with IC50 of 33 nM, 33 nM, 28 nM and 20 nM, respectively.

Aminopurvalanol A (5 and 40 μM; 8 hours) inhibits cell growth primarily by arresting the cells in the G2 phase of the cell cycle and, at higher concentration, triggering apoptosis.:Cell Cycle Analysis Cell Line:Human U937 leukemic cells Concentration:5 and 40 μM Incubation Time:8 hours Result:Increased the number of cells with a 4N DNA content as early as 8 h after the beginning of treatment at 5 μM. 40 μM led to cellular fragmentation and cells with an irregular DNA distribution, characteristic of apoptotic cell populations.Apoptosis Analysis Cell Line:Human U937 leukemic cells Concentration:5 and 40 μM Incubation Time:8 hours Result:40 μM Aminopurvalanol A led to apoptosis rather than after the beginning of treatment at 5 μM.

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Angiogenesis

CDK

Gap Junction Protein|FTO

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220792-57-4

403.91

C19H26ClN7O

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (247.58 mM)

CC(C)[C@H](CO)Nc(nc1Nc2cc(N)cc(Cl)c2)nc2c1ncn2C(C)C

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(-20℃)

With Ice Pack

≥ 2 years