Adenosine Dialdehyde (ADOX)

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

腺苷二醛是一种嘌呤核苷类似物。腺苷二醛是 S-腺苷高半胱氨酸水解酶 (SAHH) 的有效抑制剂 (Ki=3.3 nM)。腺苷二醛在体内表现出有效的抗肿瘤活性。

Adenosine dialdehyde is a purine nucleoside analogue. Adenosine dialdehyde is a potent inhibitor of S-Adenosylhomocysteine hydrolase (SAHH) (Ki=3.3 nM). Adenosine Dialdehyde exhibits potent anti-tumor activity in vivo.(In Vitro):Adenosine dialdehyde suppresses MNB cell replication in tissue culture (1.5 μM, 50% inhibition) .(In Vivo):Adenosine dialdehyde (subcutaneous injection; 1.5-2.5 mg/kg; two 7-day periods interspersed by a 7-day drug free interval( minipump infusion))increases mean life span 80% in diluent treated controls (controls, 21.3 days; AD treated 38.4 days) in mice. Adenosine dialdehyde (subcutaneous injection; 1.5-2.5 mg/kg; infused over a 7-day period ( minipump infusion)) significantly increases the mean life span of tumor bearing mice from 20.9 days in diluent treated controls to 35.3 days in AD treated animals. Adenosine dialdehyde (subcutaneous injection; 2-3 mg/kg; infused over a 7-day period ( minipump infusion)) does not exhibit any hematopoietic toxicity in mice, and it can significantly suppress murine neuroblastoma tumor growth with little systemic toxicity.

——

Animal Model:Adult male A/J mice, weighing 20 to 25 g with MNB cells Dosage: 1.5-2.5 mg/kg Administration:Subcutaneous injection; 1.5-2.5 mg/kg; two 7-day periods interspersed by a 7-day drug free interval (minipump infusion) Result:Significantly suppressed murine neuroblastoma tumor growth.Prolongs the life span of tumor bearing mice.Did not suppress hematopoiesis when administered by steady state infusion.

Adenox | Adenosine, periodate oxidized | Periodate-oxidized adenosine | Adenosinedialdehyde

Others

Other Targets

Trypsin-like proteasomes|IFN-γ

——

——

34240-05-6

265.225

——

>98% (HPLC)

In Vitro:?DMSO : 10 mg/mL (37.70 mM)

Nc1ncnc2n(cnc12)C(OC(CO)C=O)C=O

——

(-20℃)

With Ice Pack

≥ 2 years