Cinitapride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

西尼必利是一种促胃动力剂。它可以减缓肌肉的活动，从而减轻胃酸反流、胃排空延迟和溃疡性消化不良等症状。

Cinitapride is a gastroprokinetic agent. It slows the actions of the muscles to reduce the symptoms of conditions such as acid reflux, delayed gastric emptying, and ulcer dyspepsia. Cinitapride acts as an antagonist of the 5-HT2 receptors and as an agonist of the 5-HT1 and 5-HT4 receptors.

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Cinitapride (intraperitoneal injection; 0.25-1 mg/kg; once) shows gastroprotective effetcs in gastric ulceration rat model. Animal Model:Male Wistar rats with gastric ulcerationDosage:0.25-1 mg/kg Administration:Intraperitoneal injection; 0.25-1 mg/kg; once Result:Reduced haemorrhagic lesions compared with the ulcerated control group.Decreased the percentage of ulceration to 28.76% at the highest dose (1 mg/kg).Attenuated the increase myeloperoxidase activity (p<0.05, p<0.01).Increased GSH-px activity in the gastric mucosa.

Cidine | Blaston | Cinmove | Cintapro | Paxapride | cinitapride tartrate

Endocrinology/Hormones

5-HT Receptor

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66564-14-5

402.495

C21H30N4O4

>98% (HPLC)

In Vitro:?DMSO : 20.83 mg/mL (51.75 mM)

CCOc1cc(N)c(cc1C(=O)NC1CCN(CC2CCC=CC2)CC1)[N+]([O-])=O

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(-20℃)

With Ice Pack

≥ 2 years