Potent, high affinity apelin receptor agonist (IC50 = 0.27 nM; Kd = 0.51 nM). Exhibits no binding GPR15 and GPR25. Activates the PI3K/AKT pathway and promotes self-renewal of hESCs via cell-cycle progression and protein translation. Also potentiates the TGFβ pathway, priming hESCs toward the endoderm lineage. Stimulates angiogenesis in HUVEC cells. Relaxes mouse aortic vessels. Functions as an anorexigenic hormone through activation of the AVP and CRH neurons in the PVN.

Uprosertib (GSK2141795) 是一种选择性、ATP 竞争性、口服生物可利用的 Akt 抑制剂，对 Akt 1、2 和 3 的 IC50 值分别为 180 nM、328 nM 和 38 nM。

邻苯二甲酸二丁酯是大多数塑料中使用的增塑剂，存在于水、空气、土壤、植物和动物中。长期接触可能会产生一些不利影响。