Gepirone

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Gepirone HCl 是阿扎匹隆组的化合物，是属于丁螺环酮家族的 5-HT1A 受体激动剂。

Gepirone HCl is a compound of the azapirone group which is a 5-HT1A receptor agonist belonging to the buspirone family. Gepirone HCl possesses greater selectivity for the 5-HT1A receptor than SSRIs.

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Animal Model:Sprague-Dawley rats Dosage:0, 0.1, 0.3, 1 and 3 mg/kg Administration:Intraperitoneal injection (i.p.)Result:Increases in lordotic activity at lower doses. Inhibited lordosis by the 0.3 and 1.0 mg/kg doses and further inhibition was produced by the 3.0 mg/kg dose.Animal Model:Male Sprague-Dawley ratsDosage:10, 15 mg/kg Administration:Subcutaneous injection (s.c.)Result:Decreased the number of spontaneously active 5-HT neurons and firing rate.Not modified with long-term treatment with ED50 value of 10.1±0.5 μg/kg in controls and 9.7 ±1.9 μg/kg in treated rats.

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Endocrinology/Hormones

5-HT Receptor

IDH1-R132C| IDH1-R132H

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83928-76-1

359.474

C19H29N5O2

>98% (HPLC)

In Vitro:?Ethanol : 33.33 mg/mL (92.72 )

CC1(C)CC(=O)N(CCCCN2CCN(CC2)c2ncccn2)C(=O)C1

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(-20℃)

With Ice Pack

≥ 2 years