Thalidomide-O-amido-PEG-C2-NH2 hydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

沙利度胺-O-酰胺-PEG-C2-NH2 盐酸盐是一种合成的 E3 连接酶配体-接头缀合物，其中包含基于沙利度胺的 cereblon 配体和接头，可用于 PROTAC 的合成。

Thalidomide-O-amido-PEG-C2-NH2 hydrochloride, a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs.(In Vitro):PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

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Others

Other Targets

Mitochondrial Metabolism

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2204226-02-6

454.86

C19H23ClN4O7

>98% (HPLC)

In Vitro:?DMSO : 125 mg/mL (274.81 mM)

Cl.NCCOCCNC(=O)COc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12

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(-20℃)

With Ice Pack

≥ 2 years