TD-165

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

TD-165 是一种基于 PROTAC 的 cereblon (CRBN) 降解剂，包含 CRBN 配体结合基团、接头和 VHL 结合基团。

TD-165 is a PROTAC-based cereblon (CRBN) degrader comprising a?CRBN?ligand binding group, a linker and a?VHL binding group.(In Vitro):Administration of 0.1-10?μM TD-165 for 24 hours resulted in a concentration-dependent decrease in CRBN protein levels in HEK293T cells. Administration of 0-100 nM TD-165 for 24 hours showed a 50% degradation concentration (DC50) of 20.4?nM and a maximum degradation (Dmax) value of 99.6%.

TD-165 (0-100 nM; 24 hours) shows 50% degradation concentration (DC50) and maximum degradation (Dmax) value of 20.4?nM and 99.6%, respectively.TD-165 (0.1-10?μM; 24 hours) leads to a concentration-dependent decrease in the level of CRBN proteins in HEK293T cells.Cell Viability Assay Cell Line:HEK293T cells Concentration:0-100 nM Incubation Time:24 hours Result:Exhibited an DC50 value of 20.4?nM.Western Blot Analysis Cell Line:HEK293T cells Concentration:0.1, 1, and 10?μM Incubation Time:24 hours Result:Decreased the level of CRBN protein.

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Others

Other Targets

Bacterial

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2305936-56-3

870.08

C46H59N7O8S

>98% (HPLC)

In Vitro:?DMSO : 50 mg/mL (57.47 mM)

Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCCCCCCCNc2cccc3C(=O)N(C4CCC(=O)NC4=O)C(=O)c23)C(C)(C)C)cc1

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(-20℃)

With Ice Pack

≥ 2 years