Biotin-PEG4-Amide-C6-Azide ( —— )

产品货号. M26907 CAS No. 1006592-62-6

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

产品询价大包装询价加入购物车

产品名称

Biotin-PEG4-Amide-C6-Azide
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Biotin-PEG4-Amide-C6-Azide 是一种基于 PEG 的 PROTAC 连接体，可用于 PROTAC 的合成。
产品描述

Biotin-PEG4-Amide-C6-Azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.(In Vitro):PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
体外实验

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
体内实验

——
同义词

——
通路

Others
靶点

Other Targets
受体

——
研究领域

——
适应症

——

CAS Number

1006592-62-6
分子量

615.79
分子式

C27H49N7O7S
纯度

>98% (HPLC)
溶解度

In Vitro:?DMSO : 100 mg/mL (162.39 mM)
SMILES

[H][C@]12CS[C@@H](CCCCC(=O)NCCOCCOCCOCCOCCC(=O)NCCCCCCN=[N+]=[N-])[C@@]1([H])NC(=O)N2
化学全称

——

1.D T Vo, et al. Insect nicotinic acetylcholine receptor agonists as flea adulticides in small animals. J Vet Pharmacol Ther. 2010 Aug;33(4):315-22.

计算器

产品手册

关联产品

ACTH 11-24

ACTH (11-24) is a fragment of adrenocorticotrophin, induces cortisol release. ACTH (11-24) has been identified as a competitive antagonist of ACTH (1-39) and ACTH (1-10) in isolated adrenal cells.
3-Hydroxybakuchiol

3-Hydroxybakuchiol exerts cytotoxic and anti-proliferative effects on the TA3/Ha mouse mammary adenocarcinoma cell line and induces a decrease in the mitochondrial transmembrane potential, the activation of caspase-3, the opening of the mitochondrial permeability transport pore (MPTP) and nuclear DNA fragmentation.3-Hydroxybakuchiol has antitumor activity resulting from interactions with the ETC, a system that is already deficient in cancer cells.
GNE-1858

GNE-1858 是一种 ATP 竞争性造血祖激酶-1 (HPK1) 抑制剂（野生型和活性模拟突变体 HPK1-TSEE 和 HPK1-SA 的 IC50 分别为 1.9 nM、1.9 nM 和 4.5 nM）。