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Tazemetostat hydrobromide
CAS No. 1467052-75-0
Tazemetostat hydrobromide ( EPZ-6438 hydrobromide | E-7438 hydrobromide )
产品货号. M26837 CAS No. 1467052-75-0
Tazemetostat Hydrobromide 是一种有效的选择性 EZH2 抑制剂。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥331 | 有现货 |
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| 5MG | ￥472 | 有现货 |
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| 10MG | ￥738 | 有现货 |
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| 25MG | ￥1293 | 有现货 |
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| 50MG | ￥1721 | 有现货 |
|
| 100MG | ￥2799 | 有现货 |
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| 200MG | ￥4113 | 有现货 |
|
| 500MG | ￥6534 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥833 | 有现货 |
|
生物学信息
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产品名称Tazemetostat hydrobromide
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Tazemetostat Hydrobromide 是一种有效的选择性 EZH2 抑制剂。
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产品描述Tazemetostat hydrobromide is a potent and selective EZH2 inhibitor. Tazemetostat hydrobromide inhibits the activity of human polycomb repressive complex 2 (PRC2)-containing wild-type EZH2 (Ki: 2.5 nM). Tazemetostat hydrobromide also inhibits EZH1 (IC50: 392 nM).(In Vitro):Tazemetostat hydrobromide inhibits Rat EZH2 (IC50: 4 nM). Tazemetostat hydrobromide inhibits EZH2 with IC50s of 11 and 16 nM in peptide assay and nucleosome assay, respectively. Tazemetostat hydrobromide inhibits multi wild-type and mutant lymphoma cell lines proliferation with IC50s of 0.49 nM-7.6 μM .(In Vivo):Tazemetostat (250 or 500 mg/kg twice daily for 21-28 days) practically eliminates the fast-growing G401 tumors .
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体外实验——
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体内实验——
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同义词EPZ-6438 hydrobromide | E-7438 hydrobromide
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通路Chromatin/Epigenetic
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靶点Histone Demethylase
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受体microtubule
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研究领域——
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适应症——
化学信息
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CAS Number1467052-75-0
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分子量653.662
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分子式C34H45BrN4O4
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纯度>98% (HPLC)
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溶解度——
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SMILESBr.CCN(C1CCOCC1)c1cc(cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)-c1ccc(CN2CCOCC2)cc1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Ekaterina Poluektova, et al. Curvulin and Phaeosphaeride A From Paraphoma Sp. VIZR 1.46 Isolated From Cirsium arvense as Potential Herbicides. Molecules. 2018 Oct 28;23(11):2795.
