Pimonidazole hydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

盐酸哌莫硝唑通过与大分子共价结合或硝基还原后形成还原代谢物在缺氧细胞中积累。

Pimonidazole hydrochloride accumulates in hypoxic cells via covalent binding with macromolecules or by forming reductive metabolites after the reduction of its nitro group. It can be used for qualitative and quantitative assessment of tumor hypoxia. Pimonidazole hydrochloride is a novel hypoxia marker for the complementary study of tumor hypoxia and cell proliferation in tumors.(In Vitro):Pimonidazole, the exogenous hypoxia marker, is a 2-nitroimidazole compound, which forms covalent bonds with cellular macromolecules at oxygen levels below 1.3%.(In Vivo):Pimonidazole is a 2-nitroimidazole that is reductively activated specifically in hypoxic cells and forms stable adducts with thiol groups in proteins, peptides, and amino acids. Additionally, the amount of pimonidazole that is detected is directly proportional to the level of hypoxia within tumors in vivo.

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Others

Other Targets

α4β2 nAChR

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70132-51-3

290.75

C11H19ClN4O3

>98% (HPLC)

In Vitro:?DMSO : 250 mg/mL (859.85 mM)

Cl.OC(CN1CCCCC1)Cn1ccnc1[N+]([O-])=O

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(-20℃)

With Ice Pack

≥ 2 years