Org-12962

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Org-12962 是选择性，具有口服活性的 5-HT2C 受体激动剂，pEC50 值为 7.01。 Org-12962 对 5-HT2A 和 5-HT2B 受体也具有很高的作用，pEC50 分别为 6.38 和 6.28。Org-12962 在焦虑大鼠的模型中显示出缓解作用。

Org-12962 is an effective and selective 5-HT2C receptor agonist pEC50: 7.01). Org-12962 shows antiaversive effects in a rat model of panic-like anxiety. Org-12962 also shows high effacy for the 5-HT2A and 5-HT2B receptors (pEC50s: 6.38 and 6.28, respectively).(In Vivo):Org-12962 is dissolved or microsuspended in 0.3% v/v Tween 80 in physiological saline (NaCl 0.9%). Org-12962 (intraperitoneal injection; 0.3-3.2 mg/kg) obviously enhances the postinjection frequency thresholds for self-interruption (F3.71=11.40) .

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Org-12962 (intraperitoneal injection; 0.3-3.2 mg/kg) significantly increases the postinjection frequency thresholds for self-interruption (F3.71=11.40). Org-12962 is dissolved or microsuspended in 0.3% v/v Tween 80 in physiological saline (NaCl 0.9%). Animal Model:Male Wistar rats Dosage:0.3 mg/kg, 1 mg/kg, 3.2 mg/kg Administration:Intraperitoneal injection; 0.3-3.2 mg/kg Result:Induced a dose-related antipanic-like effect.

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Endocrinology/Hormones

5-HT Receptor

HCV| Nucleoside Antimetabolite/Analog

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132834-56-1

265.66

C10H11ClF3N3

>98% (HPLC)

In Vitro:?DMSO : 250 mg/mL (941.05 mM)

FC(F)(F)c1ccc(nc1Cl)N1CCNCC1

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(-20℃)

With Ice Pack

≥ 2 years