GLN-1062

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

GLN-1062 是加兰他敏的前药，在大脑中被羧酸酯酶裂解后释放加兰他敏。

GLN-1062 is a pro-drug of galantamine and liberates galantamine on cleavage by a carboxyesterase in the brain.(In Vivo):GLN-1062 has more than 15-fold higher bioavailability in the brain than the same doses of galantamine. In animal models of drug-induced amnesia, GLN-1062 produced several fold larger cognitive improvement than the same doses of galantamine, without exhibiting any significant levels of gastrointestinal side effects that are typical for the unmodified drug and other inhibitors of cholinesterases, such as donepezil and rivastigmin. In the ferret, dramatically reduced emetic and behavioral responses were observed when GLN-1062 was administered instead of galantamine.

——

——

Memogain

Others

Other Targets

Farnesyl transferase (FTase)

——

——

224169-27-1

391.467

C24H25NO4

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (255.45 mM)

[H][C@]12C[C@@H](OC(=O)c3ccccc3)C=C[C@]11CCN(C)Cc3ccc(OC)c(O2)c13

——

(-20℃)

With Ice Pack

≥ 2 years