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Gardiquimod
CAS No. 1020412-43-4
Gardiquimod ( —— )
产品货号. M26693 CAS No. 1020412-43-4
加地喹莫特可以抑制巨噬细胞的HIV-1感染并激活外周血单核细胞。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥655 | 有现货 |
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| 10MG | ￥947 | 有现货 |
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| 25MG | ￥1814 | 有现货 |
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| 50MG | ￥2688 | 有现货 |
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| 100MG | ￥3771 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥459 | 有现货 |
|
生物学信息
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产品名称Gardiquimod
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述加地喹莫特可以抑制巨噬细胞的HIV-1感染并激活外周血单核细胞。
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产品描述Gardiquimod could inhibit HIV-1 infection of macrophages and activated peripheral blood mononuclear cells. Gardiquimod is an imidazoquinoline analog and is a TLR7/8 agonist. When used at concentrations below 10?μM, Gardiquimod specifically activates TLR7.(In Vitro):Administration of 6-60?μM Gardiquimod obviously inhibits HIV-1 reverse transcriptase cDNA synthesis.(In Vivo):Gardiquimod (1 mg/kg per mouse; i.p.; daily for 7 days) in combination with Dendritic cells (DCs) enhance the anti-tumor effects of NK cells.
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体外实验Gardiquimod (6-60?μM ) significantly inhibits cDNA synthesis by HIV-1 reverse transcriptase.
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体内实验Dendritic cells (DCs) in combination with Gardiquimod (1 mg/kg per mouse; i.p.; daily for 7 days) improves the anti-tumor effects of NK cells. Animal Model:Male athymic nude mice (Balb-nu/nu, 5 weeks old) (bearing human HepG2 liver carcinoma xenografts)Dosage:1 mg/kg per mouse Administration:i.p.; daily for 7 days Result:Significantly suppressed the growth of human HepG2 liver carcinoma xenografts.
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同义词——
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通路Immunology/Inflammation
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靶点TLR
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受体Estrogen Receptor/ERR| Human Endogenous Metabolite
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研究领域——
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适应症——
化学信息
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CAS Number1020412-43-4
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分子量313.405
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分子式C17H23N5O
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纯度>98% (HPLC)
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溶解度In Vitro:?DMF : ≥ 20 mg/mL (63.82 mM)DM)
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SMILESCCNCc1nc2c(N)nc3ccccc3c2n1CC(C)(C)O
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Hernández N, et al. 4-Hydroxyestradiol improves mouse embryo quality, epidermal growth factor-binding capability in vitro and implantation rates. Mol Hum Reprod. 2021 Feb 5;27(2):gaaa075.
