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Ch55
CAS No. 110368-33-7
Ch55 ( CH 55 | Ch-55 | 3,5-Di-tert-butylchalcone )
产品货号. M26646 CAS No. 110368-33-7
Ch55 是 HL60 细胞分化的有效诱导剂 (EC50 = 200 nM)，并且与 RAR-α 和 RAR-β 受体具有高亲和力。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥900 | 有现货 |
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| 10MG | ￥1416 | 有现货 |
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| 25MG | ￥2669 | 有现货 |
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| 50MG | ￥4083 | 有现货 |
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| 100MG | ￥5652 | 有现货 |
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| 200MG | ￥7722 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
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| 1G | 获取报价 | 有现货 |
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| 1 mL x 10 mM in DMSO | ￥747 | 有现货 |
|
生物学信息
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产品名称Ch55
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Ch55 是 HL60 细胞分化的有效诱导剂 (EC50 = 200 nM)，并且与 RAR-α 和 RAR-β 受体具有高亲和力。
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产品描述Ch55 is an effective inducer of the differentiation of HL60 cells (EC50 = 200 nM) and shows high affinity with RAR-α and RAR-β receptors. Ch55 can be used in studies about cancer.(In Vitro):In rabbit tracheal epithelial cells, Ch55 inhibits type I transglutaminase activity (EC50 = 0.02 nM) and increases cholesterol sulfate levels (EC50 = 0.03 nM) thereby inhibiting squamous cell differentiation. Ch55 inhibits the induction of ornithine decarboxylase activity in 3T6 fibroblasts (EC50 = 1 nM) and induces cell differentiation of embryonic carcinoma F9 cells and melanoma S91 cells (EC50 = 0.26 and 0.5 nM). Ch55 shows a low affinity for cellular retinoic acid binding protein.
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体外实验——
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体内实验——
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同义词CH 55 | Ch-55 | 3,5-Di-tert-butylchalcone
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通路Metabolic Enzyme/Protease
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靶点Retinoid Receptor
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受体——
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研究领域——
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适应症——
化学信息
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CAS Number110368-33-7
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分子量364.48
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分子式C24H28O3
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 50 mg/mL (137.18 mM)
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SMILESCC(C)(C)c1cc(cc(c1)C(C)(C)C)C(=O)\C=C\c1ccc(cc1)C(O)=O
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Shi J, et al. Sacubitril Is Selectively Activated by Carboxylesterase 1 (CES1) in the Liver and the Activation Is Affected by CES1 Genetic Variation. Drug Metab Dispos. 2016 Apr;44(4):554-9.
