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CGP37157
CAS No. 75450-34-9
CGP37157 ( 7-Chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepine-2(3H)-one )
产品货号. M26645 CAS No. 75450-34-9
CGP37157 是一种 Na+/Ca2+ 交换抑制剂，抑制 Na+ 诱导的豚鼠心脏线粒体 Ca2+ 释放，IC50 为 0.8 μM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥378 | 有现货 |
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| 10MG | ￥662 | 有现货 |
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| 25MG | ￥1153 | 有现货 |
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| 50MG | ￥1987 | 有现货 |
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| 100MG | ￥3080 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥426 | 有现货 |
|
生物学信息
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产品名称CGP37157
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述CGP37157 是一种 Na+/Ca2+ 交换抑制剂，抑制 Na+ 诱导的豚鼠心脏线粒体 Ca2+ 释放，IC50 为 0.8 μM。
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产品描述CGP37157 is a Na+/Ca2+ exchanger inhibitor, inhibits Na+-induced Ca2+ release from mitochondria in guinea pig heart with IC50 of 0.8 μM.(In Vitro):Administration of 10?μM CGP37157 shows an inhibitory effect on mitochondrial Na+/Ca2+ exchanger in cortical neurons, modulating intracellular Ca2+ levels via suppressing voltage-gated calcium channels. Administration of 10?μM CGP37157 in combination with salinomycin significantly attenuates cell viability and increases apoptosis of FaDu and HLaC79 cells. CGP37157 has no inhibitory effect on salinomycin tumor toxicity. Administration of 10?μM CGP37157 reduces NMDA-induced cytosolic and mitochondrial Ca2+ overloads and it also reduces NMDA-induced excitotoxicity, and such an effect is via attenuating mitochondrial damage and calpain activity in neurons.
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体外实验——
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体内实验——
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同义词7-Chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepine-2(3H)-one
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通路Others
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靶点Other Targets
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受体——
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研究领域——
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适应症——
化学信息
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CAS Number75450-34-9
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分子量324.22
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分子式C15H11Cl2NOS
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : ≥ 125 mg/mL (385.54 mM)
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SMILESClc1ccc2NC(=O)CSC(c3ccccc3Cl)c2c1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Svitkin YV, et al. N1-methyl-pseudouridine in mRNA enhances translation through eIF2α-dependent and independent mechanisms by increasing ribosome density. Nucleic Acids Res. 2017 Jun 2;45(10):6023-6036.
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