Cetaben

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Cetaben 是一种不依赖于 PPARα 的过氧化物酶体增殖剂。 Cetaben是一种非纤维化降脂化合物，可有效降低胆固醇和甘油三酯浓度。

Cetaben is a PPARα-independent peroxisome proliferator. Cetaben is a non-fibrotic lipid-lowering drug that effectively reduces cholesterol and triglyceride concentrations.(In Vitro):The administration of 10 μM Cetaben for 24 hours induces severe micromorphological and ultrastructural changes in HepG2 and MH1C1 cells. After the administration of 10 μM Cetaben for 24 hours, cells were characterized by a striking heterogeneity of the peroxisomal population with the occurrence of dumbbell-shaped and cup-shaped peroxisomal profiles in MH1C1cells. After administration with 100 μM cetaben, cells contained several Golgi regions, most of them disintegrated into vesicles.(In Vivo):Administration of 50-100 mg/kg Cetaben for over 10 days shows an obvious rise in the activities of peroxisomal enzymes in both the liver and kidney. However, the maximal effect is observed at 250 mg/kg.

Cetaben (10 μM; 24 hours) induces severe micromorphological and ultrastructural changes in HepG2 and MH1C1 cells. After treatment with 100 μM cetaben, cells contained several Golgi regions, most of them disintegrated into vesicles. Cetaben-treated (10 μM; 24 hours) cells were characterized by a striking heterogeneity of the peroxisomal population with the occurrence of dumbbell-shaped and cup-shaped peroxisomal profiles in MH1C1cells.

Cetaben reveales a significant rise in the activities of peroxisomal enzymes in both the liver and kidney at doses of 50-100 mg/kg body over 10 days, but the maximal effect is observed at 250 mg/kg. Animal Model:Male Wistar rats Dosage:10,25,50,100,250 and 500 mg/kg Administration:Gavage; 10 dayResult:Revealed a significant rise in the activities of peroxisomal enzymes in both the liver and kidney at doses of 50-100 mg/kg body over 10 days, but the maximal effect was observed at 250 mg/kg.

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Others

Other Targets

Endogenous Metabolite| Influenza A

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55986-43-1

361.57

C23H39NO2

>98% (HPLC)

In Vitro:?DMSO : 25 mg/mL (69.14 mM)

CCCCCCCCCCCCCCCCNc1ccc(cc1)C(O)=O

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(-20℃)

With Ice Pack

≥ 2 years