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ZM223
CAS No. 2031177-48-5
ZM223 ( ZM-223 )
产品货号. M26524 CAS No. 2031177-48-5
ZM223 是 NEDD8 激活酶 (NAE) 的有效非共价抑制剂。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥1093 | 有现货 |
|
| 5MG | ￥1701 | 有现货 |
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| 10MG | ￥2499 | 有现货 |
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| 25MG | ￥3850 | 有现货 |
|
| 50MG | ￥5282 | 有现货 |
|
| 100MG | ￥6912 | 有现货 |
|
| 500MG | ￥13770 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称ZM223
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述ZM223 是 NEDD8 激活酶 (NAE) 的有效非共价抑制剂。
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产品描述ZM223 is a potent non-covalent inhibitor of NEDD8 activating enzyme (NAE).(In Vitro):ZM223 (0.1-1 μM) inhibits cell growth with IC50s of 100 and 122 nM in HCT-116 and U-2OS cancer cells, respectively. ZM223 (0.1-1 μM) dose-dependently reduces the level of NEDD8 and accumulation of the UBC12 protein thereby reducing the subsequent NEDD8-UBC12 complex.
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体外实验ZM223 (0.1-1 μM; 4 hours) inhibits both HCT-116 and U-2OS cancer cells with IC50s of 100 and 122 nM, respectively.ZM223 (0.1-1 μM; 4 hours) causes a dose-response decrease in the level of NEDD8 and accumulation of the UBC12 protein, indicating the decrease of the subsequent NEDD8-UBC12 complex.Cell Viability Assay Cell Line:HCT116 colon cancer cells and U-2OS osteosarcoma cells Concentration:0.1 μM, 1 μM Incubation Time:4 hours Result:Inhibited both HCT-116 and U-2OS cancer cells.Western Blot Analysis Cell Line:HCT116 colon cancer cells Concentration:0.1 μM, 1 μM Incubation Time:4 hours Result:Caused a decrease in the level of NEDD8 and an increase in the downstream UBC12 protein.
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体内实验——
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同义词ZM-223
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通路Chromatin/Epigenetic
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靶点Epigenetic Reader Domain
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受体EGFR
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研究领域——
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适应症——
化学信息
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CAS Number2031177-48-5
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分子量502.53
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分子式C23H17F3N4O2S2
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 83.33 mg/mL (165.82 mM)
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SMILESNc1ccc(SCC(=O)Nc2ccc3nc(NC(=O)c4ccc(cc4)C(F)(F)F)sc3c2)cc1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Sargeant P, Farndale RW, Sage SO. ADP- and thapsigargin-evoked Ca2+ entry and protein-tyrosine phosphorylation are inhibited by the tyrosine kinase inhibitors genistein and methyl-2,5-dihydroxycinnamate in fura-2-loaded human platelets. J Biol Chem. 1993 Aug 25;268(24):18151-6.
