ZK824190 ( —— )

产品货号. M26523 CAS No. 2254001-81-3

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

ZK824190
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

ZK824190 是一种口服选择性尿激酶纤溶酶原激活剂 (uPA) 抑制剂。
产品描述

ZK824190 is an orally available and selective inhibitor of urokinase plasminogen activator (uPA). The IC50 values are 237, 1600 and 1850 nM for uPA, tPA, and Plasmin, respectively.(In Vivo):In rats with experimental autoimmune encephalomyelitis (EAE) model, ZK824190 (2?mg/kg; p.o.) exhibited a relatively high oral availability(F?=?55%; Cmax=?0.64?g/mL and AUC?=?2.2?h*g/mL) and a moderate half time of 2.8 h.
体外实验

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体内实验

ZK824190 (2?mg/kg; PO) exhibits a relatively high oral availability and a moderate half time (T1/2=2.8 h). Animal Model:Rats with experimental autoimmune encephalomyelitis (EAE) model Dosage:2?mg/kg (Pharmacokinetic Analysis) Administration:PO Result:Oral availability F?=?55%; Cmax=?0.64?g/mL and AUC?=?2.2?h*g/mL; T1/2=2.8 h.
同义词

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通路

Others
靶点

Other Targets
受体

5-HT3
研究领域

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适应症

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1.Kilpatrick GJ, et al. 1-(m-chlorophenyl)-biguanide, a potent high affinity 5-HT3 receptor agonist. Eur J Pharmacol. 1990 Jun 21;182(1):193-7.

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