SCH-23390 maleate

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

SCH-23390maleate 是多巴胺 D1 样受体（Kis 分别为 0.2 nM 和 0.3 nM 的 1 和 D5 受体）的有效选择性拮抗剂。

SCH-23390 maleate is a potent and selective antagonist of dopamine D1-like receptor (1 and D5 receptor with Kis of 0.2 nM and 0.3 nM, respectively).(In Vitro):SCH-23390 maleate is a potent and high-efficacy agonist of the human 5-HT2C receptor (Ki = 9.3 nM). SCH-23390 maleate also binds with high affinity to the 5-HT2 and 5-HT1C receptors. SCH-23390 (1?μM) reverses the inhibitory effects of Isosibiricin on NLRP3 expression and the cleavages of caspase-1 and IL-1β in the LPS-induced BV-2 cells.(In Vivo):SCH-23390 augments dopamine-induced ductus constriction in CD-1 mouse vessels under newborn O2 conditions. SCH-23390(0.3 mg/kg i.p) is a very short-acting compound with an elimination half-life of around 25 min in the rat.

SCH-23390 (1?μM) treatment reverses the inhibitory effects of Isosibiricin on NLRP3 expression and the cleavages of caspase-1 and IL-1β in the LPS-induced BV-2 cells. SCH-23390 could reverse the Isosibiricin-mediated inhibition of the NLRP3/caspase-1 inflammasome pathway.

SCH-23390 can abolish generalized seizures evoked by the chemoconvulsants: pilocarpine and soman. SCH-23390 has also been used in studies of other neurological disorders in which the dopamine system has been implicated, such as psychosis and Parkinson's disease. Apart from the study of neurological disorders, SCH-23390 has been extensively used as a tool in the topographical determination of brain D1 receptors in rodents, nonhuman primates, and humans.SCH-23390 is a very short-acting compound with an elimination half-life of around 25 min following administration of 0.3 mg/kg i.p. in the rat.SCH-23390 augments dopamine-induced ductus constriction in CD-1 mouse vessels under newborn O2 conditions.

R-(+)-SCH-23390 maleate

Cell Cycle/DNA Damage

Potassium Channel

HCV

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87134-87-0

403.86

C21H22ClNO5

>98% (HPLC)

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OC(=O)\C=C/C(O)=O.CN1CCc2cc(Cl)c(O)cc2[C@H](C1)c1ccccc1

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(-20℃)

With Ice Pack

≥ 2 years