Picloxydine

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Picloxydine 具有抗牙菌斑和抗菌活性。吡氯昔定对细菌细胞壁和质膜具有破坏作用，导致细胞裂解和细胞内成分释放。

Picloxydine has antiplaque and antibacterial activity. Picloxydine has a destructive effect on the bacterial cell wall and plasma membrane, which leads to cell lysis and release of intracellular components.(In Vivo):While picloxydine in higher concentration suppressed the oral flora more effectively than chlorhexidine, the latter agent inhibited plaque development to a much greater extent.?This lack of correlation between antibacterial and antiplaque activity can be related to structural differences between these two bis-biguanides.

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0.4% Picloxydine produces a highly significant drop in the number of aerobic organisms. 0.4% Picloxydine is far more effective than 0.2% Picloxydine or chlorhexidine in reducing the total viable count of oral aerobic and anaerobic organisms. Picloxydine is also used in eye drops in the topical therapy of trachoma.

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GPCR/G Protein

Antibacterial

Caspase-3| Caspase-9| ERK| MEK1

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5636-92-0

475.38

C20H24Cl2N10

>98% (HPLC)

In Vitro:?DMSO : 11.36 mg/mL (23.90 mM)

Clc1ccc(NC(=N)NC(=N)N2CCN(CC2)C(=N)NC(=N)Nc2ccc(Cl)cc2)cc1

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(-20℃)

With Ice Pack

≥ 2 years