H3B-120

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

H3B-120 是一种高选择性、竞争性、变构氨基甲酰磷酸合成酶 1 (CPS1) 抑制剂 (IC50: 1.5 μM; Ki: 1.4 μM)，具有抗癌活性。

H3B-120 is a highly selective, competitive, and allosteric carbamoyl phosphate synthetase 1 (CPS1) inhibitor (IC50: 1.5 μM; Ki: 1.4 μM) with anti-cancer activity.(In Vitro):H3B-120 (25, 50, 75, 100 μM) inhibits urea production in a dose-dependent manner, although the cellular potency decreases significantly compared with enzymatic assays.?The half-life of H3B-120 is only 40 min.?H3B-120 has no inhibition of CPS2 activity of CAD (CPS2, aspartyl transcarbamylase, dihydroorotase).

H3B-120 has no inhibition of CPS2 activity of CAD (CPS2, aspartyl transcarbamylase, dihydroorotase).H3B-120 achieves inhibition by binding to an allosteric pocket situated between the integrating and ATP A domains. H3B-120 (25, 50, 75, 100 μM) inhibits urea production in a dose-dependent manner, although the cellular potency decreases significantly compared with enzymatic assays. The half-life of H3B-120 is only 40 min.

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Others

Other Targets

Akt| p38 MAPK

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2194903-42-7

372.49

C19H24N4O2S

>98% (HPLC)

In Vitro:?DMSO : 62.5 mg/mL (167.79 mM)

CN(Cc1ccccc1)C(=O)N1CCC(CC1)C(=O)Nc1nc(C)cs1

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(-20℃)

With Ice Pack

≥ 2 years