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GCN2iB
CAS No. 2183470-12-2
GCN2iB ( —— )
产品货号. M26229 CAS No. 2183470-12-2
GCN2iB 是一种 ATP 竞争性的一般控制非阻抑物 2 (GCN2) 抑制剂，IC50 为 2.4 nM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥1549 | 有现货 |
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| 10MG | ￥2527 | 有现货 |
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| 25MG | ￥4157 | 有现货 |
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| 50MG | ￥5924 | 有现货 |
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| 100MG | ￥7857 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
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| 1G | 获取报价 | 有现货 |
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| 1 mL x 10 mM in DMSO | ￥1701 | 有现货 |
|
生物学信息
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产品名称GCN2iB
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述GCN2iB 是一种 ATP 竞争性的一般控制非阻抑物 2 (GCN2) 抑制剂，IC50 为 2.4 nM。
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产品描述GCN2iB is an ATP-competitive inhibitor of general control nonderepressible 2 (GCN2) with an IC50 of 2.4 nM.(In Vitro):GCN2iB shows an IC50 value of 2.4 nM for GCN2 and potent cellular activity.?In a panel of 468 kinases, only GCN2 shows >99.5% inhibition, and three kinases (MAP2K5, STK10, and ZAK) show >95%inhibition at 1 μM GCN2iB, demonstrating high kinase selectivity.(In Vivo):In the antitumor activity study of the CCRF-CEM xenografts, ASNase or GCN2iB alone does not significantly affect tumor growth.?Notably, a combination of ASNase and GCN2iB elicits potent antitumor activity (P=0.0002) with synergistic effects.?In MV-4-11 and SU.86.86 xenografts, the robust antitumor activity of the combination of GCN2iB and ASNase is observed with a synergistic effect, respectively.?ASNase/GCN2iB-treated tumors do not show significant growth even after drug cessation.
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体外实验GCN2iB shows an IC50 value of 2.4 nM for GCN2 and potent cellular activity. In a panel of 468 kinases, only GCN2 shows >99.5% inhibition, and three kinases (MAP2K5, STK10, and ZAK) show >95%inhibition at 1 μM GCN2iB, demonstrating high kinase selectivity.
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体内实验In the antitumor activity study of the CCRF-CEM xenografts, ASNase or GCN2iB alone does not significantly affect tumor growth. Notably, a combination of ASNase and GCN2iB elicit potent antitumor activity (P=0.0002) with synergistic effects. In MV-4-11 and SU.86.86 xenografts, robust antitumor activity of the combination of GCN2iB and ASNase is observed with synergistic effect, respectively. ASNase/GCN2iB-treated tumors do not show significant growth even after drug cessation. The combination of ASNase and GCN2iB yield survival advantage compared with the vehicle treated control with synergistic effect.
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同义词——
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通路Others
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靶点Other Targets
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受体Antibacterial
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研究领域——
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适应症——
化学信息
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CAS Number2183470-12-2
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分子量451.83
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分子式C18H12ClF2N5O3S
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 50 mg/mL (110.66 mM)
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SMILESCOc1ncc(Cl)cc1S(=O)(=O)Nc1ccc(F)c(C#Cc2cnc(N)nc2)c1F
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Losch K. [Pharmacokinetic studies of sulfamerazine-Na, sulfaperine-Na and sulfadimidine-Na in the hen]. Arch Exp Veterinarmed. 1980;34(4):587-94. German.
产品手册
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