Gallopamil hydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Gallopamil HydroHClide 是苯烷基胺钙的拮抗剂。盐酸加洛帕米可用于抗心律失常和血管扩张研究。

Gallopamil hydrochloride is an antagonist of phenylalkylamine calcium. Gallopamil hydrochloride can be used in antiarrhythmic and vasodilator studies.(In Vitro):Gallopamil hydrochloride inhibits acid secretion in a concentration-dependent manner with an IC50 of 10.9 μM. (In Vivo):In male Wistar rats, Gallopamil hydrochloride (0.2 mg/kg; i.v. for 5 min) markedly reduces ventricular tachycardia and totally prevents fibrillation. Gallopamil hydrochloride significantly reduces systolic and diastolic blood pressure measured 5 min after injection without markedly influencing heart rate.

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Gallopamil hydrochloride (Methoxyverapamil hydrochloride; i.v.; 0.2 mg/kg; for 5 min) markedly reduces ventricular tachycardia (VT) and totally prevents fibrillation (VF). Gallopamil significantly reduces systolic and diastolic blood pressure measured 5 min after injection without markedly influencing heart rate. Animal Model:Male Wistar rats weighing 290-370 g Dosage:0.2 mg/kg Administration:i.v.; 5 min Result:Markedly reduced VT and totally prevented VF.

Methoxyverapamil hydrochloride

GPCR/G Protein

Calcium Channel

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16662-46-7

521.1

C28H41ClN2O5

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (191.91 mM)

Cl.COc1ccc(CCN(C)CCCC(C#N)(C(C)C)c2cc(OC)c(OC)c(OC)c2)cc1OC

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(-20℃)

With Ice Pack

≥ 2 years