Gallopamil

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Gallopamil 以浓度依赖性方式抑制酸分泌，IC50 为 10.9 μM。

Gallopamil inhibits acid secretion in a concentration-dependent manner with an IC50 of 10.9 μM. Gallopamil is a potent antiarrhythmic and vasodilator agent. Gallopamil (Methoxyverapamil), a methoxy derivative of Verapamil, is a phenylalkylamine calcium antagonist.(In Vivo):Gallopamil(5 min) significantly reduces systolic and diastolic blood pressure measured without markedly influencing heart rate. Gallopamil (0.2 mg/kg;i.v.) markedly reduces ventricular tachycardia (VT) and totally prevents fibrillation (VF).

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Gallopamil (Methoxyverapamil; i.v.; 0.2 mg/kg; for 5 min) markedly reduces ventricular tachycardia (VT) and totally prevents fibrillation (VF). Gallopamil significantly reduces systolic and diastolic blood pressure measured 5 min after injection without markedly influencing heart rate. Animal Model:Male Wistar rats weighing 290-370 g Dosage:0.2 mg/kg Administration:i.v.; 5 minResult:Markedly reduced VT and totally prevented VF.

Methoxyverapamil

GPCR/G Protein

Calcium Channel

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16662-47-8

484.637

C28H40N2O5

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (206.34 mM)

COc1ccc(CCN(C)CCCC(C#N)(C(C)C)c2cc(OC)c(OC)c(OC)c2)cc1OC

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(-20℃)

With Ice Pack

≥ 2 years