EMT inhibitor-1

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

EMT抑制剂-1是Hippo、Wnt信号传导和TGF-巨噬细胞(TGF-)的抑制剂，具有抗肿瘤活性。

EMT inhibitor -1 is an inhibitor of Hippo, Wnt signaling and TGF- macrophages (TGF-) with antitumor activity.(In Vitro):EMT inhibitor-1 (C19) inhibiting cancer cell migration, proliferation, and resistance to doxorubicin in vitro.EMT inhibitor-1 (C19) (0-10μM; 24 hours) is an inhibitor of of Hippo, TGF-β, and Wnt signaling pathways with antitumor activities.(In Vivo):EMT inhibitor-1 (C19) (intraperitoneal injection;?5-20 mg/kg) exerts strong antitumor activity in a mouse tumor model.?Mechanistically, EMT inhibitor-1 induces GSK3-β–mediated degradation of the Hippo transducer TAZ, through activation of the Hippo kinases Mst/Lats and the tumor suppressor kinase AMPK upstream of the degradation complex.C19 is dissolved in the vehicle solution (100 μL of DMEM containing 5% dimethyl sulfoxide).

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Wnt/Notch/Hedgehog

Wnt/beta/catenin

PDE4| PDE5

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1638526-21-2

319.2

C12H12Cl2N2O2S

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (313.27 mM)

OCCCCOc1nsnc1-c1ccc(Cl)c(Cl)c1

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(-20℃)

With Ice Pack

≥ 2 years