Dooku1

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Dooku1 是 Yoda1 的类似物，也是内源性 Piezo1 通道的选择性拮抗剂。

Dooku1 is an analog of Yoda1 and a selective antagonist of endogenous Piezo1 channels. Dooku1 inhibits Ca2+ entry induced by 2μMYoda1 with IC50 values of 1.3μM (in HEK 293 cells) and 1.5μM (in HUVEC). Dooku1 inhibits Yoda1-induced aortic relaxation.

Cell Viability Assay Cell Line:HUVECs, Piezo1 T-REx cells Concentration:10 μM Incubation Time:40-60 s Result:Had a concentration-dependent inhibitory effect against Yoda1-induced Ca2+ entry in HUVECs, acting with an IC50 of 1.49 μM.Increased potency in HUVECs with an EC50 of 0.23 μM, compared with 2.51 μM in Piezo1 T-REx cells.

Animal Model:wild-type male C57BL/6 mice’s aortic rings Dosage:10 μM Administration:20 min Result:Suppressed the Yoda1-induced relaxation.

——

Others

Other Targets

Bacterial

——

——

2253744-54-4

326.2

C13H9Cl2N3OS

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (306.56 mM)

Clc1cccc(Cl)c1CSc1nnc(o1)-c1ccc[nH]1

——

(-20℃)

With Ice Pack

≥ 2 years