DHODH-IN-8

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

DHODH-IN-8 具有抗疟活性。 DHODH-IN-8 是人和恶性疟原虫二氢乳清酸脱氢酶 (DHODH) 的抑制剂。

DHODH-IN-8 has antimalarial activity. DHODH-IN-8 is an inhibitor of human and Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) with IC50 of 0.13 μM and 47.4 μM, and Kis of 0.016 μM and 5.6 μM, respectively.(In Vitro):Dihydroorotic acid dehydrogenase (DHODH) is an attractive chemotherapeutic target among various pathogens, such as Plasmodium falciparum and Helicobacter pylori, and is used to treat human diseases. DHODH catalyzes the conversion of dihydroorotate (DHO) to orotate by using the FMN cofactor in the only redox reaction present in the pyrimidine biosynthesis pathway. Human DHODH (HsDHODH)a and Plasmodium falciparum DHODH (PfDHODH) are both DHODHs using respiratory quinones as terminal electron acceptors.

The dihydroorotate dehydrogenases (DHODHs) are attractive chemotherapeutic targets in various pathogens, such as Plasmodium falciparum and Helicobacter pylori, and for the treatment of human disease. DHODH catalyzes the conversion of dihydroorotate (DHO) to orotate by utilizing an FMN cofactor in the only redox reaction present in the pyrimidine biosynthesis pathway. The human DHODH (HsDHODH)a and the P. falciparum DHODH (PfDHODH) both belong to the group of class 2 DHODHs that use respiratory quinones as the terminal electron acceptors.

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Metabolic Enzyme/Protease

Dehydrogenase

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1148126-03-7

312.75

C17H13ClN2O2

>98% (HPLC)

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C\C(O)=C(/C#N)C(=O)Nc1ccc(cc1)-c1ccccc1Cl

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(-20℃)

With Ice Pack

≥ 2 years