DHODH-IN-8 ( —— )

产品货号. M26161 CAS No. 1148126-03-7

DHODH-IN-8 具有抗疟活性。 DHODH-IN-8 是人和恶性疟原虫二氢乳清酸脱氢酶 (DHODH) 的抑制剂。

纯度: >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

规格	价格/人民币	库存	数量
2MG	￥1093	有现货
5MG	￥1701	有现货
10MG	￥2499	有现货
25MG	￥3850	有现货
50MG	￥5282	有现货
100MG	￥6912	有现货
500MG	获取报价	有现货
1G	获取报价	有现货
1 mL x 10 mM in DMSO	￥1577	有现货

产品询价大包装询价加入购物车

生物学信息

产品名称

DHODH-IN-8
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

DHODH-IN-8 具有抗疟活性。 DHODH-IN-8 是人和恶性疟原虫二氢乳清酸脱氢酶 (DHODH) 的抑制剂。
产品描述

DHODH-IN-8 has antimalarial activity. DHODH-IN-8 is an inhibitor of human and Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) with IC50 of 0.13 μM and 47.4 μM, and Kis of 0.016 μM and 5.6 μM, respectively.(In Vitro):Dihydroorotic acid dehydrogenase (DHODH) is an attractive chemotherapeutic target among various pathogens, such as Plasmodium falciparum and Helicobacter pylori, and is used to treat human diseases. DHODH catalyzes the conversion of dihydroorotate (DHO) to orotate by using the FMN cofactor in the only redox reaction present in the pyrimidine biosynthesis pathway. Human DHODH (HsDHODH)a and Plasmodium falciparum DHODH (PfDHODH) are both DHODHs using respiratory quinones as terminal electron acceptors.
体外实验

The dihydroorotate dehydrogenases (DHODHs) are attractive chemotherapeutic targets in various pathogens, such as Plasmodium falciparum and Helicobacter pylori, and for the treatment of human disease. DHODH catalyzes the conversion of dihydroorotate (DHO) to orotate by utilizing an FMN cofactor in the only redox reaction present in the pyrimidine biosynthesis pathway. The human DHODH (HsDHODH)a and the P. falciparum DHODH (PfDHODH) both belong to the group of class 2 DHODHs that use respiratory quinones as the terminal electron acceptors.
体内实验

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同义词

——
通路

Metabolic Enzyme/Protease
靶点

Dehydrogenase
受体

——
研究领域

——
适应症

——

化学信息

CAS Number

1148126-03-7
分子量

312.75
分子式

C17H13ClN2O2
纯度

>98% (HPLC)
溶解度

——
SMILES

C\C(O)=C(/C#N)C(=O)Nc1ccc(cc1)-c1ccccc1Cl
化学全称

——

运输与储存

储存条件

(-20℃)
运输条件

With Ice Pack
稳定性

≥ 2 years

参考文献

1.I A Butovich, et al. Oxidation of linoleyl alcohol by potato tuber lipoxygenase: kinetics and positional, stereo, and geometrical (cis, trans) specificity of the reaction. Arch Biochem Biophys. 2000 Jun 1;378(1):65-77.

计算器

浓度计算器

摩尔计算器

分子量计算器

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