Ca2+ channel agonist 1

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Ca2+ 通道激动剂 1 是 N 型 Ca2+ 通道的激动剂和 Cdk2 的抑制剂（EC50：14.23 μM 和 3.34 μM），可用作运动神经末梢功能障碍的潜在治疗方法。

Ca2+ channel agonist 1 is an agonist of N-type Ca2+ channel and an inhibitor of Cdk2 (EC50s: 14.23 μM and 3.34 μM) and is used as a potential treatment for motor nerve terminal dysfunction.(In Vitro):Ca2+ channel agonist 1 (Compound 13d) exhibits a ca. 2-fold increased agonism and a 22-fold decreased cdk2 kinase activity versus the standard, (R)-roscovitine.

Ca2+ channel agonist 1 (Compound 13d) is an agonist of N-type Ca2+ channel and an inhibitor of Cdk2, with EC50s of 14.23 μM and 3.34 μM, respectively. Ca2+ channel agonist 1 exhibits a ca. 2-fold increased agonism and a 22-fold decreased cdk2 kinase activity versus the standard, (R)-roscovitine.

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GPCR/G Protein

Calcium Channel

Apoptosis| NF-κB

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1402821-24-2

354.458

C19H26N6O

>98% (HPLC)

In Vitro:?DMSO : 50 mg/mL (141.06 mM)

CCCn1cnc2c(NCc3ccccc3)nc(N[C@H](CC)CO)nc12

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(-20℃)

With Ice Pack

≥ 2 years