Broflanilide

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Broflanilide 代谢为去甲基-broflanilide，它是抗狄氏剂 GABA 受体的昆虫的有效拮抗剂，并抑制斜纹夜蛾 RDL GABAR，IC50 为 1.3 nM。

Broflanilide is metabolized to desmethyl-broflanilide, which is a potent antagonist at the insect resistant-to-dieldrin GABA receptor and inhibits S. litura RDL GABAR with IC50 of 1.3 nM.(In Vitro):Broflanilide is an insecticide and metabolized to desmethyl-broflanilide. Desmethyl-broflanilide shows weak activity against human GABAA α1β2γ2 receptor, the mammalian GABAA α1β3γ2 receptor and human glycine receptor (GlyR) α1β with IC50s >3 μM, and less potently inhibits GlyR α1-A288Gβ and GlyR α1-A288G with IC50s of 0.706 and 0.149 μM respectively.

Broflanilide is an insecticide and metabolized to desmethyl-broflanilide, which is a potent and selective antagonist at the insect resistant-to-dieldrin (RDL) GABA receptor, and inhibits S. litura RDL GABAR, with an IC50 value of 1.3 nM. Desmethyl-broflanilide shows weak activity against human GABAA α1β2γ2 receptor, the mammalian GABAA α1β3γ2 receptor and human glycine receptor (GlyR) α1β with IC50s of >3 μM, and less potently inhibits GlyR α1-A288Gβ and GlyR α1-A288G (IC50s, 0.706, 0.149 μM).

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Others

Other Targets

microtubule-associated protein 2

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1207727-04-5

663.285

C25H14BrF11N2O2

>98% (HPLC)

In Vitro:?DMSO : 250 mg/mL (376.91 mM)

CN(C(=O)c1ccccc1)c1cccc(C(=O)Nc2c(Br)cc(cc2C(F)(F)F)C(F)(C(F)(F)F)C(F)(F)F)c1F

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(-20℃)

With Ice Pack

≥ 2 years