2614W94

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

2614W94 是一种选择性、竞争性、可逆的单胺氧化酶-A 抑制剂，以 5-羟色胺为底物，IC50 为 5 nM，Ki 为 1.6 nM。

2614W94 is a selective, competitive, and reversible inhibitor of monoamine oxidase-A with IC50 of 5 nM and Ki of 1.6 nM with serotonin as a substrate.(In Vitro):2614W94 (30 nM) shows no inhibition of MAO-B.(In Vivo):In rats, 2614W94 (5 mg/kg, p.o.) selectively inhibits MAO-A in brains and livers and elevates neurotransmitter amines in brain, inparticular serotonin and norepinephrine, with a redcution of their oxidized metabolites. 2614W94 (0.5, 1, 2 mg/kg, p.o.) dose-dependently potentiates 5-hydroxytryptophan-induced head twitches with an extrapolated ED50 of 1.1 mg/kg.

2614W94 shows potent inhibitory activity against MAO-A, but shows no inhibition of MAO-B at 30 nM.

2614W94 (5 mg/kg, p.o.) produces selective inhibition of MAO-A in brains and livers of rats. 2614W94 (5 mg/kg, p.o.) also causes an elevation of neurotransmitter amines in brain, inparticular serotonin and norepinephrine, with a concomitant decrease in their oxidized metabolites. 2614W94 (0.5, 1, 2 mg/kg, p.o.) potentiates 5-hydroxytryptophan-induced head twitches in rats in a dose-dependent manner, with an extrapolated ED50 of 1.1 mg/kg.

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Others

Other Targets

Alkyl-Chain

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205187-35-5

344.3

C15H11F3O4S

>98% (HPLC)

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CC(Oc1ccc2c(Oc3ccccc3S2(=O)=O)c1)C(F)(F)F

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(-20℃)

With Ice Pack

≥ 2 years