BT-13

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

BT-13 是神经胶质细胞源性神经营养因子 (GDNF) 受体 RET 的选择性激动剂，与 GFL 无关。 BT-13 在体外促进感觉神经元的神经突生长。

BT-13 is a selective agonist of glial cell line-derived neurotrophic factor (GDNF) receptor RET independently of GFLs. BT-13 promotes neurite growth from sensory neurons in vitro.

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Animal Model:Rats induced by ligation of left L5 and L6 spinal nerves.Dosage:5-25 mg/kg, dissolved in sesame oil containing 5% DMSO.Administration:Subcutaneous injections on post-surgical day 1, 3, 5, 8, 10, and 12.Result:20 and 25mg/kg decreased mechanical hypersensitivity and normalized expression of sensory neuron markers in dorsal root ganglia.

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Tyrosine Kinase

c-RET

RET

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924537-98-4

517.54

C23H27F4N3O4S

>98% (HPLC)

DMSO: 25 mg/mL (48.31 mM; Need ultrasonic)

O=S(C1=CC=C(OC)C(N2CCN(C(C3=CC=C(F)C=C3C(F)(F)F)=O)CC2)=C1)(N(CC)CC)=O

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(-20℃)

With Ice Pack

≥ 2 years