Avoralstat

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Avoralstat 是一种口服血浆激肽释放酶 (PKK) 抑制剂。用于治疗遗传性血管性水肿。

Avoralstat is an oral plasma kallikrein (PKK) inhibitor. Which is used for the treatment of hereditary angioedema. (In Vitro):C1 inhibitor (C1INH) is the primary regulator of contact activation, both by inhibiting the conversion of prekallikrein to plasma kallikrein (PKK) by FXIIa, and by directly inhibiting PKK. PKK cleaves high molecular weight kininogen, releasing bradykinin, whose actions are responsible for the signs and symptoms of hereditary angioedema (HAE).

C1 inhibitor (C1INH) is the primary regulator of contact activation, both by inhibiting the conversion of prekallikrein to plasma kallikrein (PKK) by FXIIa, and by directly inhibiting PKK. PKK cleaves high molecular weight kininogen, releasing bradykinin, whose actions are responsible for the signs and symptoms of hereditary angioedema (HAE).

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BCX4161

Others

Other Targets

plasma kallikrein (PKK)

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918407-35-9

513.54

C28H27N5O5

>98% (HPLC)

DMSO:50 mg/mL (97.36 mM; Need ultrasonic)

COc(c(C=C)c1)cc(-c2ccc(C(NCC3CC3)=O)nc2C(O)=O)c1C(Nc(cc1)ccc1C(N)=N)=O

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(-20℃)

With Ice Pack

≥ 2 years