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Avoralstat
CAS No. 918407-35-9
Avoralstat ( BCX4161 )
产品货号. M24967 CAS No. 918407-35-9
Avoralstat 是一种口服血浆激肽释放酶 (PKK) 抑制剂。用于治疗遗传性血管性水肿。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥497 | 有现货 |
|
| 10MG | ￥758 | 有现货 |
|
| 25MG | ￥1516 | 有现货 |
|
| 50MG | ￥2409 | 有现货 |
|
| 100MG | ￥3447 | 有现货 |
|
| 200MG | ￥4707 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥563 | 有现货 |
|
生物学信息
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产品名称Avoralstat
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Avoralstat 是一种口服血浆激肽释放酶 (PKK) 抑制剂。用于治疗遗传性血管性水肿。
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产品描述Avoralstat is an oral plasma kallikrein (PKK) inhibitor. Which is used for the treatment of hereditary angioedema. (In Vitro):C1 inhibitor (C1INH) is the primary regulator of contact activation, both by inhibiting the conversion of prekallikrein to plasma kallikrein (PKK) by FXIIa, and by directly inhibiting PKK. PKK cleaves high molecular weight kininogen, releasing bradykinin, whose actions are responsible for the signs and symptoms of hereditary angioedema (HAE).
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体外实验C1 inhibitor (C1INH) is the primary regulator of contact activation, both by inhibiting the conversion of prekallikrein to plasma kallikrein (PKK) by FXIIa, and by directly inhibiting PKK. PKK cleaves high molecular weight kininogen, releasing bradykinin, whose actions are responsible for the signs and symptoms of hereditary angioedema (HAE).
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体内实验——
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同义词BCX4161
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通路Others
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靶点Other Targets
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受体plasma kallikrein (PKK)
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研究领域——
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适应症——
化学信息
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CAS Number918407-35-9
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分子量513.54
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分子式C28H27N5O5
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纯度>98% (HPLC)
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溶解度DMSO:50 mg/mL (97.36 mM; Need ultrasonic)
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SMILESCOc(c(C=C)c1)cc(-c2ccc(C(NCC3CC3)=O)nc2C(O)=O)c1C(Nc(cc1)ccc1C(N)=N)=O
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Aygoren-Pursun E, et al. Prophylaxis of hereditary angioedema attacks: A randomized trial of oral plasma kallikrein inhibition with avoralstat. J Allergy Clin Immunol. 2016 Sep;138(3):934-936.e5.
产品手册
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