2OH-BNPP1 ( —— )

产品货号. M24823 CAS No. 833481-73-5

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

2OH-BNPP1
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

2OH-BNPP1 是一种 BUB1 激酶，一种 Ser/Thr 激酶抑制剂，用于治疗癌症。
产品描述

2OH-BNPP1 is a BUB1 kinase, a Ser/Thr kinase inhibitor, it used for the treatment of cancer.
体外实验

2OH-BNPP1 (0.1-50 μM) abrogates TGFβ signaling in a dose dependent manner. 2OH-BNPP1 dose-dependently impairs the TGFβ-induced phosphorylation of proteins that mediate canonical and non-canonical TGFβ signaling in multiple cancer cell lines and normal cell lines.
体内实验

2OH-BNPP1 (50 mg/kg) blocks TGFβ signaling in vivo, and significantly decreases abundance of phosphorylated SMAD2 in tumor-bearing mice.
同义词

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通路

Others
靶点

Other Targets
受体

BUB1 kinase
研究领域

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适应症

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1.Nyati S, et al. The kinase activity of the Ser/Thr kinase BUB1 promotes TGF-β signaling. Sci Signal. 2015 Jan 6;8(358):ra1.

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