AMN082

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

AMN082 是一种代谢型谷氨酸受体 7 变构激动剂。

AMN082 is a metabotropic glutamate receptor 7 allosteric agonist.

Preincubation of the synaptosomes with AMN082 (1 μM) for 10 min before 4-aminopyridine treatment efficiently inhibits the 4-aminopyridine-evoked release of glutamate, without altering the basal release of glutamate.

AMN082 (6 mg/kg; p.o.) induces stress hormone increases in an mGluR7-dependent fashion in mGluR7+/+ mice (C57BL/6 genetic background).AMN082 (1.25-5.0 mg/kg, i.p.; 30 min before every Cocaine injection during repeated drug administration or before Cocaine challenge) dose-dependently attenuates the development, as well as the expression of Cocaine locomotor sensitization.

——

Neuroscience

GluR

mGluR7

——

——

83027-13-8

392.54

C28H28N2

>98% (HPLC)

In Vitro:?DMSO : 12.5 mg/mL (31.84 mM)

C(CNC(c1ccccc1)c1ccccc1)NC(c1ccccc1)c1ccccc1

——

(-20℃)

With Ice Pack

≥ 2 years