Hirsutine

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Hirsutine 诱导细胞凋亡，是一种有效的登革热病毒抑制剂，具有低细胞毒性。

Hirsutine induces apoptosis and is a potent Dengue virus inhibitor exhibiting low cytotoxicity.Hirsutine has anticancer, cardioprotective, anti-hypertensive and anti-arrhythmic activities, it also has vasodilatation activity, the mechanism is related to blockade of Ca2+ influx through L-type Ca2+ channels and inhibition of intracellular Ca2+ release may have no relationship with K+ channels.

Hirsutine remarkably reduces the viability of MCF-7 and MDA-MB-231 cells in a time- and dose-dependent manner with IC50 values of 447.79 and 179.06 μM, respectively. In the MDA-MB-231 cells, Hirsutine induces apoptosis and depolarization of MMP, releases Cyt C from mitochondria, and activates caspase 9 and caspase 3.

Hirsutine induces mPTP-dependent apoptosis through ROCK1/PTEN/PI3K/GSK3β pathway in human lung cancer cells.

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Apoptosis

Apoptosis

Apoptosis

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7729-23-9

368.47

C22H28N2O3

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (271.39 mM)

O=C(OC)/C([C@H]([C@H](CN1CC2)CC)C[C@]1([H])C3=C2C(C=CC=C4)=C4N3)=C/OC

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(-20℃)

With Ice Pack

≥ 2 years