021-51111890
购物车（）
sales@molnova.cn
ICI 118,551 hydrochloride
CAS No. 72795-01-8
ICI 118,551 hydrochloride ( ICI 118551 hydrochloride )
产品货号. M24738 CAS No. 72795-01-8
ICI 118,551 是一种高选择性 β2 肾上腺素受体拮抗剂（Kis：对于 β2、β1 和 β3 受体分别为 0.7、49.5 和 611 nM）。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥364 | 有现货 |
|
| 10MG | ￥585 | 有现货 |
|
| 25MG | ￥1070 | 有现货 |
|
| 50MG | ￥1572 | 有现货 |
|
| 100MG | ￥2277 | 有现货 |
|
| 200MG | ￥3411 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥643 | 有现货 |
|
生物学信息
-
产品名称ICI 118,551 hydrochloride
-
注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
-
产品简述ICI 118,551 是一种高选择性 β2 肾上腺素受体拮抗剂（Kis：对于 β2、β1 和 β3 受体分别为 0.7、49.5 和 611 nM）。
-
产品描述ICI 118,551?is a highly selective β2 adrenergic receptor antagonist (Kis: 0.7, 49.5, and 611 nM for β2, β1, and β3 receptors).(In Vitro):Zenidolol (ICI-118551) hydrochloride inhibits cAMP accumulation with IC50 of 1.7 μM in IMCD cells.Zenidolol (ICI-118551; 10 μM) hydrochloride induces a prominent vasorelaxation of norepinephrine (NE)-precontracted PA but not AO.In failing human heart, Zenidolol (ICI-118551) hydrochloride has significant effects on beat duration, with time-to-peak contraction and time-to-90% relaxation reduced compared with basal contraction. Negative Inotropic Effect of Zenidolol (ICI-118551) hydrochloride Is Not cAMP-Related. Overexpression of β2AR in rabbit myocytes enhances negative inotropic effects of Zenidolol (ICI-118551) hydrochloride.(In Vivo):Zenidolol (ICI-118551; 0.2 mg/kg) hydrochloride injected into the jugular vein of the mice, reduces systolic pressure in the pulmonary circuit but not systemic arterial pressure.
-
体外实验Zenidolol (ICI-118551) hydrochloride inhibits cAMP accumulation with IC50 of 1.7 μM in IMCD cells. Zenidolol (ICI-118551; 10 μM) hydrochloride induces a prominent vasorelaxation of norepinephrine (NE)-precontracted PA but not AO. In failing human heart, Zenidolol (ICI-118551) hydrochloride has significant effects on beat duration, with time-to-peak contraction and time-to-90% relaxation reduced compared with basal contraction. Negative Inotropic Effect of Zenidolol (ICI-118551) hydrochloride Is Not cAMP-Related. Overexpression of β2AR in rabbit myocytes enhances negative inotropic effects of Zenidolol (ICI-118551) hydrochloride.
-
体内实验Zenidolol (ICI-118551; 0.2 mg/kg) hydrochloride injected into the jugular vein of the mice, reduces systolic pressure in the pulmonary circuit but not systemic arterial pressure.
-
同义词ICI 118551 hydrochloride
-
通路Others
-
靶点Other Targets
-
受体β2 receptor|β1 receptor|β3 receptor
-
研究领域——
-
适应症——
化学信息
-
CAS Number72795-01-8
-
分子量313.86
-
分子式C17H28ClNO2
-
纯度>98% (HPLC)
-
溶解度DMSO : 20 mg/mL (63.72 mM; Need ultrasonic) H2O : 11 mg/mL (35.05 mM; Need ultrasonic)
-
SMILESCC1=C(CCC2)C2=C(OC[C@H](O)[C@@H](C)NC(C)C)C=C1.[H]Cl
-
化学全称——
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1.Yasuda G, et al. The beta 1- and beta 2-adrenoceptor subtypes in cultured rat inner medullary collecting duct cells. Am J Physiol. 1996 Sep;271(3 Pt 2):F762-9.
产品手册
关联产品
-
YK-4-279
YK 4-279 是一种 RNA 解旋酶 A (RHA) 抑制剂，可与致癌转录因子 EWS-FLI1 结合。
-
Araloside X
Aralosides possess protective effect against experimental myocardial ischemia and infarction, the mechanism of myocardial protection may be attributed to the amelioration of FFA metabolic deterioration and membrane peroxidation induced by oxygen free radicals. Aralosides have anti-inflammatory effect, they also can effectively prevent acute alcoholic liver injury.
-
5-Hydroxy-4a,8-dimet...
The herbs of Inula hupehensis.
